Course Catalog

1-D and 2-D NMR Spectroscopy: Structure Determination of Small Molecule Organic Compounds

Explore the fundamentals of sample preparation, solvent choice, pulse sequence selection, parameter optimization, data processing options, and data interpretation of one and two-dimensional homo- and heteronuclear experiments.

Course Details

Key Topics

  • NMR Hardware Review
  • 1-D and 2-D NMR Experiment Selection
  • Homonuclear and Heteronuclear 2-D NMR Interpretation
  • NMR Structural Elucidation Strategy
  • 1-D and 2-D NMR Processing Packages

Information

Students will use one and two dimensional NMR Spectroscopy to elucidate the structure of small molecule unknowns. The course will explore the fundamentals of sample preparation, solvent choice, pulse sequence selection, parameter optimization, data processing options, and data interpretation of one and two-dimensional homo- and heteronuclear experiments. Each of the NMR experiments listed in the agenda will be discussed in detail. Data interpretation will include a discussion of various NMR software (i.e. ACD, TOPSPIN, VNMR, Mnova) as well as analysis using plotted spectra. Data sets will be analyzed using three formats during the course: instructor lead analysis, individual/small group problem sets, and independent analysis of NMR problem sets.

Who Should Attend

Any chemist who would like to improve their NMR interpretation skills that works in the pharmaceutical, consumer products, food science, forensics, or cosmetics industry.

Benefits

  • Minimize data analysis time
  • Optimize NMR experiment selection
  • Improve NMR data interpretation skills
  • Understand the role of NMR in structural elucidation
  • Optimize experimental NMR parameters
  • Enhance NMR vocabulary

Agenda

  • 1-D Experiments
    • 1H
      • Chemical shift
      • Coupling constants
      • Integration
      • First order splitting patterns
      • Proton exchange
      • Presaturation
    • 13C
      • Proton decoupling
      • Chemical shift
      • Coupling constants
    • DEPT/APT
    • Other nuclei (19F, 15N, B, etc.)
    • 1-D NOE
      • Difference
      • Gradient selected
  • 2-D Experiments
    • Homonuclear
      • COSY/TOCSY
      • NOESY/ROESY
      • INADEQUATE
    • Heteronuclear
      • 1H-X Direct Bond
        • HETCOR
        • HSQC/HMQC
      • 1H-X Multiple Bond
        • COLOC
        • HMBC
        • HSQC-TOCSY
    • NMR Problem Solving Strategy
      • Experiment Selection
        • 1-D versus 2-D
        • Hydrogen versus Carbon
        • Homonuclear versus Heteronuclear
      • Experiment Optimization
        • Pulses
        • Delays
        • Maximizing Sensitivity
      • NMR Software
        • TOPSPIN
        • VNMR
        • ACD
        • MNova

Course Locations

Date

March 17 - 18, 2018

Check-in opens at 7:30 a.m. on the first day of the course.

Course runs from 8:30 a.m. to 5:00 p.m. each day.

Register Online Register Via Mail

Venue

TBA


Pricing
  Member Non-Member
Advanced $1,695 (Ends Feb 17) $1,895 (Ends Feb 17)
Standard $1,895 $2,095

The course fee includes a course binder and a continental breakfast each day.

Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax or mail and mention this discount. May not be combined with any other offer.

Date

August 18 - 19, 2018

Check-in opens at 7:30 a.m. on the first day of the course.

Course runs from 8:30 a.m. to 5:00 p.m. each day.

Register Online Register Via Mail

Venue

TBA


Pricing
  Member Non-Member
Advanced $1,695 (Ends Jul 18) $1,895 (Ends Jul 18)
Standard $1,895 $2,095

The course fee includes a course binder and a continental breakfast each day.

Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax or mail and mention this discount. May not be combined with any other offer.

About the Instructors

  • Greg Walker

    is a Senior Principal Scientist at Pfizer Inc with 20+ years of experience in the pharmaceutical industry.

  • Kathleen Farley

    is a Principal Scientist in the R&D division at Pfizer Inc with over 25 years of experience in the pharmaceutical industry.