Course Catalog

Analysis and Interpretation of Mass Spectral Data

This class, for researchers, technicians, and others requiring knowledge and skill in mass spectral interpretation, will teach you to quickly and accurately interpret data from mass spec analysis.

This class is run in an environment that promotes open discussion of concepts, and stresses fundamentals and real-life experiences.

Course Details

Key Topics

  • Strategic procedure that will be immediately helpful in interpreting mass spectra.
  • How to use template motifs for structure identification of unknown metabolites, impurities, and degradants.
  • How to identify metabolites of busipirone; impurities of Paclitaxel (TAXOL) in drug substances; degradants of Sotalol in drug products.
  • How to profile impurities and degradants of butorphanol.
  • Preferred industry formats and platforms of mass analyzers
  • Important applications in ionization – including EI, CI, ESI, and APCI
  • Overview of LC/MS fundamentals, including chromatographic separations, method development, and transfer of HPLC methods to LC/MS.

 

Information

This class, for researchers, technicians, and others requiring knowledge and skill in mass spectral interpretation, will teach you to quickly and accurately interpret data from mass spec analysis.

This class is run in an environment that promotes open discussion of concepts, and stresses fundamentals and real-life experiences.

Who Should Attend

Researchers, technicians, and others requiring knowledge and skill in mass spectral interpretation and who wish to learn run in an environment that promotes open discussion of concepts, fundamentals, and real-life experiences.

A basic knowledge of chemistry is required; course work is organic chemistry is desirable.

Participants should bring a basic calculator to the course.

Benefits

    • Build a solid foundation in interpreting mass spectra, which will include a working knowledge of analytical instrumentation; analytical considerations and perspectives; and industry benchmarks and trends.

    • Consult with a leading expert about your mass spectral problems.
    • Learn strategies which will be immediately helpful in interpreting mass spectra, including the Nitrogen Rule; naturally occurring stable isotopes; molecular confirmation and validation; MS/MS template approaches; and reaction classification.
    • Learn from case studies and carefully chosen, real-life exercises that will reinforce your learning.

    • Gain an in-depth understanding of MS-based applications.

    • Become familiar with industry applications and preferences.

Agenda

    • Introduction to Chemical Bonding in Organic Molecules as it Pertains to Mass Spectrometry

    • How the E1 Mass Spectrum is Formed: Rules and Principles

    • Naturally Occurring Stable Isotope Abundances and Their Role in Peak Intensity

    • The Molecular Ion

    • Fragmentation As It Relates to Structure, Elemental Composition, and Compound Type

    • Mass Spectra of High Molecular Weight Components

    • MS/MS Mass Spectra: What Are They and How Do We Deal with Them?

    • Fragmentation of Specific Compound Types: Aliphatic and Aromatic Hydrocarbons, Alcohols, Mines, Acids, Aldehydes, and Ketones

    • Library Searches and Mixed Spectral Data

    • Chemical Ionization and Electron Ionization Used Together to Determine the Identity and Structure of an Unknown.

Course Locations

Date

November 8 - 9, 2017

Check-in opens at 7:30 a.m. on the first day of the course.

Course runs from 8:30 a.m. to 5:00 p.m. each day.

Register Online Register Via Mail

Venue

MicroTek
350 10th Avenue Suite 950
San Diego, CA 92101


Pricing
  Member Non-Member
Advanced $1,495 (Ends October 6) $1,695 (Ends October 6)
Standard $1,895 $2,095

The course fee includes a course binder and a continental breakfast each day.

Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax or mail and mention this discount. May not be combined with any other offer.

About the Instructor

  • Mike Lee

    is a biotechnology entrepreneur and Founder and President of Milestone Development Services. He actively participates in the development of new technologies and their integration into industrial settings. Dr. Lee has more than 25 years of pharmaceutical industry experience. He has pioneered the application of LC/MS for research dealing with biomolecules, optimization of ADME and physicochemical properties, natural products, drug metabolites, impurities, and degradants.