Course Catalog

Introduction to Drug Metabolism: Role and Practice in Drug Discovery and Development

Learn about generating, interpreting, and using drug metabolism data to support drug discovery?from lead selection and optimization to drug registration.

Course Details

Key Topics

  • Optimal ADME properties of a drug candidate.
  • Common biotransformation reactions and enzymes. Application examples.
  • Optimization of lead compounds from the drug metabolism perspective.
  • Assessment and minimization of structural liabilities associated with drug metabolism.
  • Typical drug metabolism experiments for drug discovery and development.
  • Regulatory consideration and PhRMA perspective on drug metabolism (including MIST).


Learn about generating, interpreting, and using drug metabolism data to support drug discovery?from lead selection and optimization to drug registration.

Who Should Attend

Scientists and managers in the medicinal and analytical chemistry and drug metabolism fields of the pharmaceutical and chemical industries and academic labs who want to learn about the applications of drug metabolism. Attendees should have a basic understanding of organic chemistry, analytical chemistry, and/or biochemistry.


  • Gain practical drug metabolism knowledge.
  • Understand how to effectively interpret and use drug metabolism data.
  • Recognize drug metabolism issues such as DDI and formation of reactive or toxic metabolites.
  • Learn how to minimize drug liabilities associated with drug metabolism.
  • Be able to design basic in vitro and in vivo drug metabolism studies.
  • Get familiar with drug metabolism packages required for IND and NDA filing and for drug label.
  • Become familiar with analytical tools in drug metabolism studies.


  • Common metabolic reactions and common metabolism enzymes (CYP, UGT, SULT) and polymorphisms
  • In vitro drug metabolism models
  • Strategy/methodology for screening and minimizing reactive metabolites
  • Reaction phenotyping, CYP inhibition and induction for DDI potential
  • Lead optimization examples
  • Common analytical tools including LC/MS and radioactivity detection
  • Metabolite identification strategies and metabolite profiling in the first-in-man study
  • Design of animal and human ADME studies ? comparative metabolic profiling

Course Locations



Check-in opens at 7:30 a.m. on the first day of the course.

Course runs from 8:30 a.m. to 5:00 p.m. each day.

Register Online Register Via Mail


The course fee includes a course binder and a continental breakfast each day.

Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. This discount is only available if you register by fax or mail and mention this discount. May not be combined with any other offer.

  Member Non-Member
Advanced $895 (ends July 15, 2014) $1,095 (ends July 15, 2014)
Standard $1,095 $1,295

About the Instructors

  • Dr. Donglu Zhang

    is a Principal Scientist at Bristol-Myers Squibb in Princeton, NJ. Dr. Zhang has frequently taught short courses at ACS and EAS, is a co-editor of the book ?Drug metabolism in drug design and development?, a co-inventor of mass defect filtering technology, and has published >60 peer-reviewed articles.

  • Dr. Ragu Ramanathan

    is an Associate Director in the Department of Biotransformation at Bristol-Myers Squibb, Princeton, NJ. With over 20 years of experience in mass spectrometry, Dr. Ramanathan?s primary focus of research involves application of LC-MS for pharmaceutical drug discovery and development.