Course Catalog

Organic Synthesis: Methods and Strategies for the 21st Century Chemist

Bring your mastery of synthetic organic chemistry right up to the current year!

This course is intended for any chemist who requires knowledge of the most recent methods in organic synthesis. The course materials also cover the strategies by which syntheses of organic compounds are designed and are continuously updated from the current literature right up to the time of each presentation of the course. The vast majority of the materials are from the 2000?s supplemented with some older references provided for the purpose of placing the most modern methods in a proper historical perspective.

Course Details

Key Topics

  • The most important methods of synthetic organic chemistry in the context of their applications to actual syntheses.
  • Basic concepts of strategy in designing syntheses of organic compounds.
  • Recent developments in enantioselective synthesis.
  • Modern organometallic coupling reactions.
  • Current aspects of carbanion, carbocation, radical, and carbene chemistry
  • Construction of carbocyclic systems.
  • Use of enzymes and other biological techniques in synthesis.

Information

Bring your mastery of synthetic organic chemistry right up to the current year!

This course is intended for any chemist who requires knowledge of the most recent methods in organic synthesis. The course materials also cover the strategies by which syntheses of organic compounds are designed and are continuously updated from the current literature right up to the time of each presentation of the course. The vast majority of the materials are from the 2000′s supplemented with some older references provided for the purpose of placing the most modern methods in a proper historical perspective.

Who Should Attend

Chemists who are involved in any aspect of laboratory or manufacturing operations concerned with the preparation of organic compounds and who wish to acquire a stronger background in the modern methods of organic synthesis and the strategies by which syntheses of organic compounds may be designed.

Organic chemistry instructors wishing to update their own courses with the most recent developments in the field.

The course will be invaluable to chemists at any level of training (B.S., M.S., or Ph.D.) who need a refresher or who feel their knowledge is becoming out of date. Relatively recent Ph.D.’s in synthetic organic chemistry or others who have kept up with the literature are less likely to benefit from the course.

Registrants are encouraged to bring a small set of molecular models for use in the course.

Benefits

  • Refresh and update your knowledge of synthetic organic methods.
  • Learn the latest on enantioselective reactions and catalytic organometallic reactions.
  • Become familiar with the increasingly important applications of enzymes, catalytic antibodies, and other biological methods in organic chemistry.
  • Gain an exposure to modern approaches for designing syntheses of complex organic compounds.
  • See the applications of synthetic strategy and methods by means of numerous examples of actual syntheses taken from the original literature.
  • Obtain an extensive compilation of references to the current synthetic organic chemistry literature right through the current year.

Agenda

  • Introductory Concepts – Strategy for designing syntheses; synthetic equivalency; protecting groups.
  • Enantioselective Synthesis – Basic concepts; enantioselective reagents and catalysts; biological methods.
  • Organometallic Coupling Reactions ? Summary of this very active field for formation of carbon-carbon and carbon-heteroatom bonds.
  • Enolates and Enol Derivatives – Regio- and stereoselective enolate formation and alkylation; Michael reactions; aldol condensations; Mannich reactions.
  • Carbocation Reactions – Alkene cyclization and polycyclization reactions.
  • Radical Cyclization Reactions – Use of azo compounds, organic halides and other initiator groups; tandem cyclizations; group transfer reactions.
  • Carbene, Carbene Complexes and Other Carbene-Like Species – Addition to alkenes and alkynes; carbene insertion reactions.
  • Cycloadditions – Intramolecular Diels – Alder reaction; 4 + 2 cycloadditions; 3 + 2 cycloadditions; 2 + 2 cycloaddition reactions; higher-order cycloadditions.

Supplementary materials will be provided for the following topics:

  • Ring -forming reactions - employing enolates and related intermediates
  • Ene, Carbonylation, and Other Cyclization Reactions- Ene reaction; diene, allene and alkyne cyclizations; electrocyclic ring closure of 1,3-dienes; carbonylation reactions.
  • lkene Synthesis- Wittig reaction and modifications; Peterson reaction of silanes; Julia condensation of sulfones; use of transition metal alkylidene reagents; alkene and alkyne metathesis reactions; organometallic addition to alkynes.
  • Rearrangements- Cyclopropane derivatives; Grob and related fragmentations; Cope and Claisen rearrangements.

Course Locations

Date

June 21 - 22, 2017

Check-in opens at 7:30 a.m. on the first day of the course.

Course runs from 8:30 a.m. to 5:00 p.m. each day.

Register Online Register Via Mail

Venue

MicroTek
230 West Monroe Street Suite 900
Chicago, IL 60606


Pricing
  Member Non-Member
Advanced $1,495 (Ends May 19) $1,695 (Ends May 19)
Standard $1,895 $2,095

The course fee includes a course binder and a continental breakfast each day.

Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax or mail and mention this discount. May not be combined with any other offer.

Date

August 19 - 20, 2017

Check-in opens at 7:30 a.m. on the first day of the course.

Course runs from 8:30 a.m. to 5:00 p.m. each day.

Register Online Register Via Mail

Venue

TBA
TBA
Washington, DC 20036


Pricing
  Member Non-Member
Advanced $1,495 (Ends July 19) $1,695 (Ends July 19)
Standard $1,895 $2,095

The course fee includes a course binder and a continental breakfast each day.

Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax or mail and mention this discount. May not be combined with any other offer.

Date

November 6 - 7, 2017

Check-in opens at 7:30 a.m. on the first day of the course.

Course runs from 8:30 a.m. to 5:00 p.m. each day.

Register Online Register Via Mail

Venue

MicroTek
350 10th Avenue Suite 950
San Diego, Ca 92101


Pricing
  Member Non-Member
Advanced $1,495 (Ends October 6) $1,695 (Ends October 6)
Standard $1,895 $2,095

The course fee includes a course binder and a continental breakfast each day.

Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax or mail and mention this discount. May not be combined with any other offer.

About the Instructor

  • Paul Helquist

    is Professor and Associate Chair of Chemistry and Biochemistry at Notre Dame; Director of Project Development Team for translational therapeutics research at Notre Dame and other universities in Indiana.