Course Catalog

Pharmacokinetics and Pharmacodynamics in Drug Discovery for Chemists - Special Topics

This one-day, Special Topics course is designed to increase understanding of the fundamental concepts governing drug pharmacokinetics (ADME studies) as they are utilized in new drug discovery. The course consists of lectures on the biological concepts and assays used for the pharmacokinetics description of in vivo drug action (ADME estimation of the concentration of the drug at the target). Emphasis is placed on the use of ADME principles to chemically optimize favorable druglike activity and reduce unfavorable side effects. Additionally, in course exercises are used to illustrate principles.

Course Details

Key Topics

  • Assessment of Druglike activity for new molecular entities
  • In vitro Pharmacokinetic tests for Permeation and Drug Metabolism
  • Understanding of Drug Clearance (Renal, Hepatic)
  • Drug Absorption and Distribution (Volume of Distribution)
  • In vivo Pharmacokinetics, allometric scaling for prediction of activity in humans
  • In silico predictions of pharmacokinetic and safety issues

Information

This one-day, Special Topics course is designed to increase understanding of the fundamental concepts governing drug pharmacokinetics (ADME studies) as they are utilized in new drug discovery. The course consists of lectures on the biological concepts and assays used for the pharmacokinetics description of in vivo drug action (ADME estimation of the concentration of the drug at the target). Emphasis is placed on the use of ADME principles to chemically optimize favorable druglike activity and reduce unfavorable side effects. Additionally, in course exercises are used to illustrate principles.

Who Should Attend

Scientists (medicinal chemists, analytical chemists, biologists, pharmacologists) in the pharmaceutical, chemical and cosmetic industries needing a basic understanding of PK/PD concepts and illustration of practical applications. Others who would benefit are toxicologists, regulatory affairs and clinical professionals

Benefits

  • Learn PK/PD principles and jargon to enable you to have more productive interaction with drug development colleagues.
  • Understand the relationships among parameters used to characterize drug disposition, absorption and response.
  • Understand how to obtain and calculate important parameters and their limitations.
  • Better understand the candidate selection process that is based on PK/PD criteria.
  • See the application of these principles in drug development from literature examples.
  • Appreciate the role of drug metabolism in candidate selection.
  • Understand the relevance of non-linear behavior in absorption and disposition.
  • Be better equipped to function in matrixed interdisciplinary drug development teams.
  • Learn about first-time-in-humans dosing issues.

Agenda

  • ADME principles / Absorption / Principles and in vitro assays
  • Drug metabolism / microsome & hepatocyte data
  • Clearance- hepatic and renal
  • Volume of distribution / multiple dosing
  • Oral Bioavailability and Bioequivalence / non linear PK
  • Evaluation of in vivo PK data Pharmacodynamics / evaluating affinity and efficacy
  • Troubleshooting PK issues
  • Review and Discussion

Course Locations

Date

TBA

Check-in opens at 7:30 a.m. on the day of the course.

Course runs from 8:30 a.m. to 5:00 p.m.

Register Via Mail

Venue

The course fee includes a course binder and a continental breakfast each day.

Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax or mail and mention this discount. May not be combined with any other offer.


Pricing
  Member Non-Member
Early $795 (ends December 31, 2012) $795 (ends December 31, 2012)
Advanced $895 $1,095
Standard $1,095 $1,295

About the Instructor

  • Terry Kenakin

    has spent 32 years in industrial drug discovery, has won numerous awards for pharmacological research (Gaddum Memorial Award: 2014, Ariens Award: 2011, Poulsson Medal: 2008, IUPHAR Analytical Pharmacology Award: 2006), authored over 250 peer reviewed papers and reviews and written 10 books on Pharmacology.He also is Editor-in-Chief of Journal of Receptors and Signal Transduction and Co-Editor-in-Chief of Current Opinion in Pharmacology. He currently is Professor of Pharmacology at the University of North Carolina School of Medicine, Chapel Hill NC.