Course Catalog

Practical Applications of Mass Spectrometry for Small Molecules

Mass spectrometry is a rapidly evolving technique – the instruments and knowledge of 10 years ago is not relevant today due to the sheer force of its popularity creating new and improved instruments and techniques at lower cost available to everyone.The course develops from a comprehensive focus on understanding the fundamentals of the most widely used mass spectrometers and sample inlet technologies. The examples include how designing the separation, handling the sample and its preparation and avoiding pitfalls of combining LC, GC and MS can increase analytical success. Discussion includes the latest technologies such as non-LC atmospheric ionization techniques for GC and desorption techniques such as DESI, DART, ASAP.

In addition to the ACS course materials copy of the ‘The Mass Spectrometry Primer’ (2009) is included free of charge in the cost of the course (ISBN 1-879732-04-1 $49.50).

Course Details

Key Topics

  • Who uses which types of instruments and for what – do I always need accurate mass and how accurate a result do I need?
  • How and where are the techniques employed to the practitioners’ best advantage?
  • Examining how we interact with the analytical systems as operators – avoiding frustration and increasing useful uptime.
  • Understanding the output – when can I trust my results?

Information

Mass spectrometry is a rapidly evolving technique – the instruments and knowledge of 10 years ago is not relevant today due to the sheer force of its popularity creating new and improved instruments and techniques at lower cost available to everyone. The course develops from a comprehensive focus on understanding the fundamentals of the most widely used mass spectrometers and sample inlet technologies. The examples include how designing the separation, handling the sample and its preparation and avoiding pitfalls of combining LC, GC and MS can increase analytical success. Discussion includes the latest technologies such as non-LC atmospheric ionization techniques for GC and desorption techniques such as DESI, DART, ASAP.

In addition to the ACS course materials copy of the ‘The Mass Spectrometry Primer’ (2009) is included free of charge in the cost of the course (ISBN 1-879732-04-1 $49.50).

Who Should Attend

The course is designed for anyone in pharma, industry or environmental practice employing MS for small molecule investigations including design of experiment considerations (column chemistries, solvents and ionization methods), quantitative considerations, qualitative considerations (spectral interpretation) and identification of target compounds in complex matrices.

In addition to course materials, references for further study and glossaries explaining commonly used terms, the take-home value of attending for students is gaining an overall view of current mass spectrometry practice and the opportunity to address individual questions.

Benefits

  • Understand the basics of one of the most widely used analytical tools today.
  • Access to a wide array of knowledge from the instructor’s 25 years researching and writing about mass spectrometry.
  • Take home understanding of the steps involved in successfully employing mass spectrometry to your current situation whether you are an operator, manage in-house MS capabilities or are outsourcing your needs.
  • Understand the limitations and capabilities of mass spectrometry as an analytical tool so you can trust your results.

Agenda

  • Who Uses MS?
  • What is a Mass Spectrometer? How do they work?
    • How large a molecule can I analyze?
    • Isotope and elemental mass spectrometry
    • The analyzer: heart of the mass spectrometer
    • Electron ionization (EI)
    • Gas chromatography (GC)
    • Liquid chromatography (LC) (should be included as complimentary to GC and then introduces ESI/APCI))
    • Electrospray (ESI)
    • Atmospheric Pressure Chemical Ionization (APCI)
    • Alternative ionization techniques
      • Atmospheric pressure photoionization (APPI)
      • Matrix assisted laser desorption (MALDI)
      • Fast atom bombardment (FAB)
      • Desorption
        • Plasma desorption
        • Secondary ion MS (SIMS)
        • Field desorption
        • Desorption ESI
  • A Brief History
  • What Types of Instruments are in Use?
    • Quadrupoles and magnetic sectors
    • Ion traps and other non-scanning instruments
      • Fast-fourier transform ion cyclotron
      • Time-of-Flight
    • Hybrids
      • QTOF
      • Ion mobility
  • Data Handling
    • Data output, storage and retrieval
  • Mass Accuracy and Resolution
    • High mass accuracy and low resolution
    • How much accuracy is needed?
    • How can we compare precision among instruments?
    • Terminology
  • Interpreting the Output of the Mass Spectrometer
  • Quantitation and Calibration
  • Solvents and Caveats for LCMS
    • Ion suppression
    • Column chemistries

Course Locations

Date

February 21 - 22, 2018

Check-in opens at 7:30 a.m. on the first day of the course.

Course runs from 8:30 a.m. to 5:00 p.m. each day.

Register Online Register Via Mail

Venue

MicroTek
Cypress Center One 5404 Cypress Center Drive, Suite 125
Tampa, FL 33609


Pricing
  Member Non-Member
Early
Advanced $1,695 (Ends Jan 21) $1,895 (Ends Jan 21)
Standard $1,895 $2,095

The course fee includes a course binder and a continental breakfast each day.

Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax,mail or phone and mention this discount and may not be combined with any other offer.

About the Instructor

  • Michael Balogh

    is a technology consultant and former consulting principal scientist and Director of Strategic Collaborations at Waters Corporation.