On Demand

Solid State Characterization of Organic Compounds

Gain a sound understanding of the basic principles of high-performance liquid chromatography.

On Demand
6 Modules
Each Module
$199
Registration Info

About the Course

This course is an introduction to solid state characterization of organic molecules. Techniques include x-ray powder diffraction (XRPD), thermal methods spectroscopic methods, and water uptake.

For each technique, basic theory is presented along with its application to organic molecules. Information on instrumentation, sample preparation, and data analysis is included in the modules. Use of the technique to differentiate and quantitate solid forms (polymorphs) is discussed and case studies are presented to show how the measurements were used in real life situations.

  • XRPD theory and best practices
  • Thermal analysis methods and how they are used together
  • Spectrometric methods overview and when to use them
  • Water sorption measurements and how to determine when water may be an issue
  • Case studies to show how the techniques were used to solve real world problems

What You Will Learn

  • Learn about a variety of analytical techniques and gain information that you can apply directly to your job
  • Understand how solid forms can affect your project and how to spot them early before they become a major issue
  • Help your company put the best data in your patent and regulatory documents

Who Should Attend

Anyone who works with organic molecules, such as synthesis, crystallization, characterization, analysis, use, formulation, physical and chemical stability.

Organic chemists, process chemists, materials scientists, analytical chemists, pharmaceutical scientists, formulation scientists, patent attorneys.

Managers and supervisors who need a basic understanding of solid form characterization and how it will affect their ultimate goals will also find this course useful.

Course Outline

  • Module 1. X-Ray Powder Diffraction (XRPD) 

    • Diffraction basics
    • Instrumentation (geometry, detectors, data collection modes)
    • Sampling issues (preferred orientation, particle size)
    • Variable temperature XRPD
    • Data Analysis
    • Quantitation
    • Case study
  • Module 2. Thermal Methods

    • Differential scanning calorimetry (DSC)
      • Overview
      • Calibration
      • Sample preparation
      • Measurements and data analysis (enthalpy of fusion, glass transition temperature)
    • Hot stage microscopy
      • Instrumentation
      • Use
    • Thermogravimetry (TG)
      • Instrumentation
      • Use
      • Thermogravimetry-infrared (TG-IR) measurements
    • Determination of thermodynamic stability
    • Monotropic vs enantiotropic systems
      • Energy temperature diagrams
      • Quantitation
      • Case study
  • Module 3. Infrared (IR) Spectroscopy

    • Theory
    • Instrumentation
    • Sampling Techniques (DRIFTS, ATR, imaging)
    • Variable temperature IR
    • Near- IR (NIR)
    • Data Analysis
    • Quantitation
    • Case Study
  • Module 4. Raman Spectroscopy

    • Theory
    • Instrumentation
    • Sample preparation
    • In-situ measurements (crystallization studies, RH, hot and cold stage microscopy)
    • Applications (form identification, form conversion, interactions, processing, stability, screening)
    • Imaging
    • Quantitation
    • Case Study
  • Module 5. NMR Spectroscopy

    • Theory
    • Solid state NMR
    • Solution NMR
    • Applications (solvent identification, interactions, salts/cocrystal identification, mixture analysis, suspensions, reactions)
    • Quantitation
    • Case Study
  • Module 6. Water Sorption

    • Water-solid interactions (absorption, adsorption, deliquescence)
    • Automated instrumentation
    • Data collection, analysis, and interpretation
    • Relative humidity chambers
    • Hygroscopicity flow chart, how to determine if water will be an issue, strategies to deal with problematic materials
    • Case studies included in the various sections

Dates, Locations, and Prices

On Demand course modules can be purchased a la carte for $199, each. All modules are held on a rolling basis throughout the year to accommodate your schedule and budget.

On Demand

Online

Standard Member $199 Non-Member $199
Become a member during registration
- Less Details+ More Details

The registration fee includes seven days of access to the content, lecture slides (provided in PDF format), and email access to the instructor. Each person attending must register individually for this course.

To complete your registration, you will be asked to log in using your ACS ID. If you are not already logged in, you may enter your credentials or create an ID from the next screen.

Log in or Register Now

About the Instructor(s)

Ann Newman

Pharmaceutical Consultant, Seventh Street Development Group

Dr. Ann Newman is currently a pharmaceutical consultant at Seventh Street Development Group with more than 20 years of large pharma and contract research experience. She teaches Polymorphism in Organic/Pharmaceutical Systems.

On Demand
6 Modules
Each Module
$199
Registration Info