Pharmacokinetics for Chemists in Drug Discovery and Development

Discover concepts and tools required to make molecules suitable to be drug candidates (i.e., be absorbed, distribute throughout the body, be present to produce effect, and cause no harm).

Key topics include:

• Drug-like properties of molecules
• Absorption (IV, oral, other routes)
•  Volume of distribution
• Metabolism (hepatic assays, clearance)
• Excretion (renal clearance)
• In vivo PK (PK-PD models, allometric scaling)
• Drug-drug interactions (hepatic, nonlinear PK)
• Candidacy for human studies

• Medicinal and synthetic organic chemists
• Biologists involved in drug development
• Any scientist involved in process of drug discovery, production and approval